After coming out strong in the first quarter, the Spartans (2-0) saw the Eagles (0-2) get back in the game by allowing two touchdowns late in the closing minutes of the first half.
With the score 24-17 at half, it once again appeared that the Spartans were having trouble for the second consecutive week against an obviously weaker opponent.
The Spartans received the ball from the second half kickoff and kick returner Javon Ringer fumbled the ball, which was recovered by the Eagles.
EMU was threatening to tie the game deep in Spartan territory but only managed to move two yards in three plays, having to kick a 38-yard field goal. That field goal would be the last time the Eagles would score in the game.
Drew Stanton led the offense to two touchdowns in the third quarter; the first was a 1-yard touchdown rush on a quarterback option and the second touchdown was an 8-yard connection between Stanton and freshman receiver T.J. Williams.
Stanton opened the fourth quarter with a 7-yard touchdown pass to senior Matt Trannon, who had a historic day receiving. Stanton was finished for the day after that touchdown, handing duties over to backup Brian Hoyer.
Stanton finished having completed 23 of 31 passes for 239 yards and three touchdowns while also rushing nine times for 40 yards and two touchdowns.
The running game was also working all day for the Spartans. Javon Ringer rushed for 130 on 15 carries and A.J. Jimmerson made his Spartan debut by rushing for 79 yards on 10 carries while also catching 3 balls for 46 yards and two touchdowns.
One of Jimmerson's touchdowns was a pass from Matt Trannon, who took a handoff from Drew Stanton and proceeded to throw to a wide open Jimmerson on the opposite side of the field for a 35-yard touchdown.
Brian Hoyer completed all four of his passes in the fourth quarter, throwing a 5-yard touchdown to Jimmerson.
Michigan State outscored Eastern Michigan 28-3 in the second half to make a statement against their cross-state foes from about 55 miles away.
MSU improves to 7-0 in the series history with EMU, winning every game convincingly.
Next week, the Spartans travel to Pittsburgh in a showdown of 2-0 teams.